Jayasekara, J. M. K. BDissanayake, D. MGunaratna, M. D. NThilakarathna, SSivakanesan, R2024-03-012024-03-012011-11-24Peradeniya University Research Session PURSE -2011, Proceeding and Abstracts, Vol.16,24th November, 2011, University of Peradeniya, PP. 92https://ir.lib.pdn.ac.lk/handle/20.500.14444/160Health professionals inSri Lanka havenoticed ahigh incidence of anewformof chronic kid!leydisease of unknown aetiology (CKO-U) infarmers ofNorthCentral Region (NCR). neaimof thestudywas to identify the risk factors related to farming inorder to implement oreventive strategies. Potential agricultural risk factors and other information were collected through interviewer-administered questionnaires given to 315 CKO-U patients anI 321 healthy controls that were randomly selected. The relative risk of each factor was cornpared in terms ofOdds ratios (ORs) and95%confidence interval (CI) by applying th.. linear logisticmodel. In-olvernent In paddy farming activities (OR = 1.945. 95%CI: 1.256-3.010) usage of aqro-chemicals (OR=2.034, 95%CI: 1297-3.190), poor preventive measures when usin.. agro-chemicals (OR = 2845. 95% CI. 1788-4527), high operated paddy extent WithJutexchange of labour (OR= 4734, 95%CI: 2.586-8.665) were identified as significant ·;ontributory risk factors forCKO-U (p<0.005). Cultivating a large landextent without hiri 19 labour was asignificant risk factor for thedisease (p<005) Furthermore. cultivating ·.maller landextent without hired labour (OR= 1558,95% CI .047-1.56) had higher risk thancultivating larger landextent with hired labour (OR= 140. 95%CI: 042142j Inatdition to the agricultural activities. being amale. age> 60 years. smoking. alcoholism. family history of CKO-U. history ofmalaria and snake bites (p<0.05) were identified a;other contributory factors.<formular> It ere IS a strong occupational risk factor in the pathogenesis of the disease where the 11alefarmers of >60 of age were at a high risk probably due to long term exposure t,) the aetiotoqical agents (risk factors) Agricultural activities involvinq intense physical acivity were related toCKO-U Further studies are indicated to identify theeffect of dehydraion and physical exertion on the renal functions of these individuals. Poor preventive measures inagrochemical usage related to thedisease indicate the need to educate th{ farmers onsafeagrochemical usage.en-USAgriculturalKidney DiseasePathologyMedicineMathematicsBiochemistryMedical Laboratory SciencesArticle