PURSE 1996

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https://ir.lib.pdn.ac.lk/handle/20.500.14444/43

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Browsing PURSE 1996 by Author "De Silva, D. D. N."

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    Histopathological Changes in the Nervous System of Goats Affected with Enterotoxaemia
    (University of Peradeniya, Peradeniya, 1996-08-10) De Silva, D. D. N.; Gunawardena, S. P. G. De S.
    Enterotoxaemia caused by the toxins of Clostridium perfringens type D is an important disease of sheep and goats with a world wide distribution. The clinical manifestation of this condition is often associated with signs characteristic of nervous system disorders. Therefore, this investigation is aimed at studying the lesions in the nervous system of the goats affected with enterotoxaemia. Four Beetal goats with neurological manifestations, and belonging to the Nikaweratiya farm were included in this study. The animals aged between 2-4 years started showing neurological signs such as opisthotonus, ataxia, salivation, circling and nystagmus with a variable degree of paresis. Two of the animals were quadriplegic and showed excessive salivation, rapid breathing and hyperaesthesia. These severely affected animals succumbed to the condition within 36 hours after the onset of signs. Detailed necropsy and histopathological examinations were performed on the two dead animals and one animal which was sacrificed. Urine analysis and a toxicological study using intestinal contents for mouse inoculation were also performed. Necropsy revealed congestion and oedema of the lungs, hyperaemia 'and petechial haemorrhages in the small intestines and pulp like consistency of kidneys. Urine analysis revealed presence of glucose and protein. Presence of clostridial toxins in the intestines was demonstrated by the mouse inoculation test. Histological lesions were seen in the brain of all affected animals. These cerebral lesions were characterized by symmetrical focal areas of encephalomalacia. The early lesions showed oedema and the leakage of plasma and red blood cells from the veinules and capillaries in the affected areas. These lesions are characteristic of Enterotoxaemia and are useful in differentiating Enterotoxaemia from other neurological diseases in goats such as cerebrospinal nematodiasis and hypocalcaemia
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    Role of Electrocadiography in Diagnosis of Canine Cardiac Arhythmias- a Case Report
    (University of Peradeniya, Peradeniya, 1996-08-10) Jayasooriya, L. J. P. A. P.; Pakiarajah, P.; De Silva, D. D. N.; Wijekoon, M. P. A.; Fernando, P. R. I.; Kalupahana, R. S.
    Electrocardiography is a useful diagnostic tool in veterinary medicine. An electrocardiogram (E.C.G.) is quickly and easily recorded and interpreted. Also the information obtained is reliable. It is essential in the diagnosis and treatment of cardiac arrhythmias. A 7-year-old female Dalmatian was referred to the Veterinary Teaching Hospital with a history of gradual loss of appetite, polydipsia, a dry cough and with enlarged abdomen. On clinical examination rectal temperature was 101 "P. Heart rate and arterial pulse rate were 124 beats/min. The oral and ocular mucosae were pale. The other symptoms included congested lungs, splenomegaly and hepatomegaly. Abnormal heart sounds also were detected on auscultation. An electrocardiogram was recorded and a lead II rhythm strip recorded at a paper speed of 25 mmlsec and sensitivity of 1 cm = 1 mV, is presented in this report. Cardiac rhythm was irregular due to the occurrence of unifocal ventricular premature complexes (VPCs). VPCs were not associated with P waves and were characterized by bizarre QRS complexes with large amplitude. The major QRS deflection was negative. In addition to VPCs, P waves may have been replaced by baseline F waves suggesting the presence of atrial flutter. VPCs are mostly associated with cardiac abnormalities such as congestive heart failure, pericarditis, cardiomyopathy or myocarditis. Atrial flutter can be associated with chronic mitral valvular fibrosis, ruptured chordae tendinae, or ventricular pre-excitations. Subject showed a considerable improvement with digoxin therapy. But sudden death occurred after a week following hypothermia and dyspnoea. Necropsy revealed cardiomegaly, blood tinged pericardial fluid, left atrioventricular valvular endocardiosis and thinning of ventricular walls.