Controversies on the Aetiology of Endemic Goitre in Sri Lanka
| dc.contributor.author | Areseculeratne, Y. M. | |
| dc.contributor.author | Reginald, G. J. | |
| dc.contributor.author | Hemawardana, D. M. | |
| dc.contributor.author | Weerasekara, G. A. B. | |
| dc.contributor.author | Tammita, A. | |
| dc.date.accessioned | 2024-01-12T09:15:38Z | |
| dc.date.available | 2024-01-12T09:15:38Z | |
| dc.date.issued | 1996-08-10 | |
| dc.description.abstract | Endemic goitre is widely prevalent in the wet zone en Sri Lanka. The exact aetiology of endemic goitre has not been fully understood though iodine deficiency has been thought to be the commonest cause. This study involved the investigation of hundred and eleven euthyroid goitrous female patients with regard to their thyroid status. The gland was assessed according to the classification endorsed by the WHO and the International Council for the Control of Iodine Deficiency Disorders (lCCIDD), and categorised into 3 grades. The tests included measurement of total serum thyroxine, triiodothyronine and thyroid stimulating hormone levels and 2 and 24 hour iodine uptakes following the administration of a tracer dose of radioactive iodine. Thyroid hormone levels were found to be within the specified 'normal' ranges, but a trend was observed whereby an increase in goitre size was associated with a fall in total serum thyroxine levels, which was not significant, a rise in total triiodothyronine, being significant between grades 2 & 3 (p < 0.05), and a significant fall in serum thyroid stimulating hormone levels between grades 1 & 2 (p < 0.03), as well as between grades 2 & 3 (p < 0.05). The radioactive iodine uptakes at both 2 & 24 hours showed a rise with increase in the size of the gland, the uptakes between grades 2 & 3 were significant in both instances, (p < 0.01) and (p < 0.05) respectively. The biochemical picture seen in these patients is not in keeping with that seen in patients from areas en confirmed iodine deficiency. | |
| dc.identifier.citation | Proceedings of the Annual Research Sessions, August 10,1996, Uninversity of Peradeniya, Peradeniya, Sri Lanka, pp 67-85 | |
| dc.identifier.isbn | 955-589-011-0 | |
| dc.identifier.uri | https://ir.lib.pdn.ac.lk/handle/20.500.14444/90 | |
| dc.language.iso | en_US | |
| dc.publisher | University of Peradeniya, Peradeniya | |
| dc.subject | Agriculture | |
| dc.subject | Aetiology | |
| dc.subject | Endemic goitre | |
| dc.subject | Sri Lanka | |
| dc.title | Controversies on the Aetiology of Endemic Goitre in Sri Lanka | |
| dc.type | Article |