Chemistry & activity of Acronychia Pedunculata fruits

Abstract

Chemical investigation on the hexane and dichloromethane extracts of the fruits of Acronychia pedunculata (L.Miq.) has resulted in the isolation of six compounds including two novel compounds, 7-acetyl-4,6-dihydroxy-5-(methyl-2-buteny]}-2-(1- methyl-ethylbenzofuran and a new benzopyran derivative. They were isolated along with three known acetophenone derivatives, acrovestone, demethyiacrovestone and demethylacronylin and the sesquiterpene, clovan-2,9-diol. While demethylacrovestone has been previously isolated from Acronychia pedunculata fruits, acrovestone is isolated from Acronychia pedunculata fruits for the first time although it has been isolated from its bark and demethylacronylin has been reported to be present in Acronyehia laurifolia. Clovan-2,9-diol is being reported from Acronychia species for the first time. Biological activities of these compounds were evaluated against the second instar larvae of dedes aegypti. Acrovestone and the new benzofuran derivative showed moderate activity with LC(50) of 3.6 ppm and 2.5 ppm while the new benzopyran and demethylacrovestone showed weak activity with LC(50) of 10 ppm and 12.5 ppm respectively.