Is the pattern of invasion a reliable predictor of metastasis of oral cancer
Date
2000-12-16
Authors
Siriwardena, B. S. M. S.
Tilakaratne, W. M.
Journal Title
Journal ISSN
Volume Title
Publisher
University of Peradeniya
Abstract
Although oral cancer accounts for over 35% of all the cancers in our patients, there is no reliable way to predict prognosis. Various studies have shown different relationship of histological features to prognosis. but the results are not conclusive. Arrangement of cells at the advancing front of the tumour may playa significant role in predicting prognosis. Metastasis is considered as a key clinical and histological parameter which decides the outcome of a given patient. Therefore the aim of this study was to compare the relationship between the pattern of invasion and metastasis.
Fifty cases of oral squamous cell carcinoma which have been excised with the neck lymph nodes, received at the Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya from July 1999 to August 2000 were selected for this study. Pattern of invasion has been graded as type 1.2.3, and 4 according to the arrangement of tumour cells at the advancing front.
Statistical analysis showed metastasis of 22% in type 2. 50% in type 3, and 71% in type 4 oral squamous cell carcinoma patients. These results were statistically significant and the p value was 0.001 <p<O.OI.
In conclusion, pattern of invasion is a reliable predictor for metastasis of oral squamous cell carcinoma. Therefore this histological parameter may be of use in planning treatment of oral Squamous cell carcinoma.
Description
Keywords
Dental , Sciences Oral Cancer
Citation
Proceedings and Abstract of the Annual Research Sessions, December 16, 2000, University of Peradeniya, Sri Lanka pp 88-93