Effects of co-enzyme Q-10 on healing of microulcers on Gingiva of adults
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Date
1998-11-07
Authors
Chandrasekera, A.
Journal Title
Journal ISSN
Volume Title
Publisher
University of Peradeniya
Abstract
Bleeding gingiva is an important symptom to the patient as well as a significant
sign for the dental practitioner. Micro-ulcers in the gingiva is the cause of gingival
bleeding and the slightest trauma will lead to bleeding. The Micro-ulcers are formed at the
attached epithelium initially and spreads to the crevicular epithelium subsequently.
Healing of an ulcer is time conswning. Therefore, even though the plaque control is good,
the bleeding gingiva will persist for a longer period of time. Periodontal researchers are
concerned with this problem. They have used various substances to reduce the healing
time of the gingival microulcers. Co-enzyme Q 10 is one such substance.
Co-enzyme Q10 or ubiquinone is an endogenous quinine. It is an essential link in
the respiratory chain of cells of the inner mitochondrial membranes. This means that co-
enzyme Q 10 is of fundamental importance for continuous mitochondrial synthesis of
adenosine tri-phosphate the main source of cellular energy. In this study the effect of co-
enzyme QlOon the healing of gingival ulcers will be studied.
40 subjects were selected for the study. 20 in 21 - 30 age group, 9 in the 31 - 40
age group and 11 in the 41 - 50 age group. 15 were male and 25 were female. They were
otherwise healthy subjects with mild to moderate adult periodontitis. The American
academy of periodontology classification was used to diagnose the type of periodontal
disease. The type of periodontitis was diagnosed considering the bleeding on probing
(BOP), loss of attachment (LOA), radiographic bone loss, topography and mobility of
teeth. Bleeding on probing is present in both mild and moderate adult periodontitis, loss
of attachment is less in mild form which is less than 4 mm and moderate form it is >4mm
and <6 mm. Radiographic bone loss is severe in both conditions. In the moderate type
more sites are involved. There is no mobility in the mild type in contrast to the grade I
mobility seen in the moderate type.
The plaque index (PLI) and the bleeding index (BI) were recorded. The plaque
control methods were started and scaling was done where it was necessary. Half the group
was given 30mg Co-enzyme Q 10 (BioquinouslPharma Nord) and the rest were given a
placebo. The patients were monitored in two weeks, one month, two months, three months
and four months intervals and PLI and BI recorded.
Preliminary studies of our research has suggested a decrease in gingival bleeding
among the subjects who were given Co-enzyme QI0 (P<O.02). Therefore, Co-enzyme QI0
may be used as an adjuvant in the treatment of adult periodontitis.
Description
Keywords
Co-enzyme , Microulcers , Health Sciences
Citation
Proceedings & Abstracts of the Annual Research Sessions,1998,University of Peradeniya, peradeniya, Sri Lanka, pp 39