Studies of the immunological response of puppies, monkeys and children to toxocara canis (Werner, 1782)i nfectiion
| dc.contributor.author | Vasudevan, Bundla | |
| dc.date.accessioned | 2024-09-10T05:29:02Z | |
| dc.date.available | 2024-09-10T05:29:02Z | |
| dc.date.issued | 1971-01 | |
| dc.description.abstract | The course of the naturally sequired grenatal infec- tion of 7, canis in pupples from their birth to 4 menthe of age wae followed, The feecal Joxpcgrg egg count trends, the antibody response and the Toxoqgrg worm burden2xapinalin at pon-mrmnieiw on death or after being killed at lflfi daye of age in these puppics heve been reperted v l!:mumn: 1), . - -was of the effects of n}cunroeuen en pupriee - aged 4 to 6 weeks and naturelly infected with Joxocgrs Y '§ ‘wae made ('«‘xpoflmnt 2 end 3). ¢ R The pattern of oimhmry anti-Toxpegrg sntibodies i *n been studied in theee pnppxu aperinfected with diffe- v Pent doses and in those which received rcingle and multiple fl"' of T,csnig infective ova by megns of conglutinating complement absorption test and Cuchterlony ager diffusion bit.tl. Attempts have been made w,gvom'ehts the serelogi- eal rescticone ss meagured by the conglutinating complement Ml‘pgm test (C.C.A.T) with the Joxpogra worm egs count h'nndl and p.fimlmen effects of npcunueuun. Super infection. Puppies naturally infected with T.canis showed marked pesistance to superinfection by doses of 5000 to 20,000 But lorger doses of 50,000 to 100,000 ova eften Resulted in the death of the puppies, It has been shown In this sudy that the immunity soguired from a natural infection can be reinforeed by superinfection with a mode- rate does or 10,000 infective ova to enable the animals to withstand a challenge with a lerge does of 100,000 infective ova. - In_ the puppies supersnfected with large doses of 80000 to 100000) ova most of the existing infection Was not necessarily accompanied by resistence to the re- infection or to its effects, Acguired immunity te J,ognis on in puppies scems to be menifested at least in i wayst (1) by preventing the development of larvee produced by superinfection beyond the second-stage in the lungs their migration to the intestine mainly to produce the fourth stage end (11) by enabling the host to withetand pathological effects of superinfection which are fatal in non-immune puppies, The pathological effect of a superinfection in none Immune puppies is manifested by extenuvp necrosie of the Hepatie parenchymal cells with concomitant inorease of the Serum glutamine pyruvate trengaminese (S0P-T) activity Which are less marked in the immune puppies. | |
| dc.identifier.uri | https://ir.lib.pdn.ac.lk/handle/20.500.14444/877 | |
| dc.language.iso | en | |
| dc.publisher | University of Peradeniya | |
| dc.subject | Health | |
| dc.subject | Immunology | |
| dc.title | Studies of the immunological response of puppies, monkeys and children to toxocara canis (Werner, 1782)i nfectiion | |
| dc.type | Thesis |